Coenzyme Q10 Review: Benefits, Dosage, Side Effects (2019 Study) 5/5 (2)

Coenzyme Q10

Coenzyme Q10 also known as CoQ10 is an essential nutrient that mimics the properties of antioxidants in the body. At the same time, it is a coenzyme which enhances the function of enzymes in the body. But is it worth supplementing?

Improves heart health

Boosts brain health

Has immense anti-aging potential

May cause nausea and vomiting

Can lower blood sugar levels

May cause blood pressure to dip

Coenzyme Q10 Review

Enzymes in the body have many important functions to perform. By definition, these are biological molecules that speed up the rate of almost every chemical reaction taking place within cells.

Coenzyme Q10

Coenzyme Q10

For instance, digestive enzymes make it possible to digest food, releasing the energy locked in nutrients. Others break down larger molecules into smaller pieces making them more readily absorbed by the body. And yet others bind two molecules to produce a new one.

In any case, the reactions that occur as a result of enzymatic action speed up bodily processes significantly. But to function optimally, enzymes need help from something called coenzymes. These natural compounds assist enzymatic action by generating the energy needed by the body.

In this instance, CoQ10, a naturally produced vitamin-like substance in the body is the most important coenzyme. Its primary role is the creation of cellular energy and it is present in the tissue of organs such as the brain, heart, kidneys, and liver.

However, it is present in its inactive form known as ubiquinone in the body and needs to be converted into the active form that goes by the name of ubiquinol. This is the form that helps generates the energy needed for vital organs to perform optimally.

When converted into ubiquinol, CoQ10 also starts acting like an antioxidant that can help neutralize free radical damage. This is something that ubiquinone cannot do.

Another point of difference between the two forms is absorbability. Ubiquinone or conventional CoQ10 is not as efficiently absorbed by the body. However, when the same converts to ubiquinol, it becomes more bioavailable and gets absorbed more readily in the intestinal tract. [1]

Starting around the age of 30, the body starts having a harder time converting conventional CoQ10, or ubiquinone into ubiquinol. Anyone suffering from diabetes, congestive heart failure, and cancer often present lowered plasma levels of coQ10. That is why supplementation becomes important both through the diet and via high-quality supplements.

Coenzyme Q10 Benefits

For aging individuals, measuring CoQ10 levels is very important. Any shortage of this coenzyme can lead to oxidative stress, which in turn increases the risk for a range of disorders. Proper supplementation can prevent this and offer the following benefits as well:

1. Coenzyme Q10 Sustains Natural Energy

For sustaining sufficient energy in the cells of the body, there are tiny organelles known as mitochondria. These are responsible for turning fat and other nutrients into useable sources of energy. CoQ10 helps with this process.

It does so by accepting electrons during glucose and fatty acid metabolism and transferring them to electron acceptors. [2] This process of energy transfer from its raw form into its usable form is crucial to every cell in the human body. To maintain energy levels this synthesis needs CoQ10 to do its job. [3]

Another take on energy production is CoQ10’s ability to improve exercise-related fatigue. [4]

Coenzyme Q10 Review

Coenzyme Q10 Review

2. Coenzyme Q10 Lowers Oxidative Damage

But energy production is not its only function. In fact, alongside generating cellular energy it also acts as a protective agent by defending cells against free radical damage.

Also known as oxidative stress, this type of damage changes cellular structure which manifest itself as age-associated functional decline.

Being both water and fat soluble antioxidant, coenzyme Q10 can inhibit lipid peroxidation. In other words, when LDL gets oxidized, CoQ10 is one of the first antioxidants that help offset the effects. This coenzyme has been found to protect DNA and membrane proteins within mitochondria from oxidative damage. [5]

3. Coenzyme Q10 Improves Heart Health

CoQ10 shows immense potential for preventing and treating various heart conditions. This is believed given its antioxidant potential and its ability to improve cellular biogenetics. Some areas where it can potentially help heart health include reducing the risk for repeat heart attack and lowering blood pressure.

One area of special interest is CoQ10’s ability to combat the side effects associated with cholesterol-lowering statins. Studies show that when hen supplementing with CoQ10, individuals can increase their HDL-C even when taking statins. This can help lower the risk for cardiovascular disease.

Although statin therapy can significantly lower stroke and heart attack risk, users often suffer from side effects like weakness and muscle aches. But using CoQ10 helps reduce such pain and presents the potential for higher compliance with the treatment. [6]

4. Coenzyme Q10 And Anti-aging Effects

To discuss this point, you need to revisit the concept of mitochondrial synthesis. So long as this mechanism works at a good rate, your muscles, bones, skin and healthy tissue won’t suffer. But impaired or slow metabolism can change all this.

With CoQ10 levels declining with age, your energy metabolism also follows suits which result in degeneration of organs. To keep CoQ10 supplied up with supplementation, researchers believe that age-related decline can be slowed down, especially in terms of DNA damage.

As such, the anti-aging benefits of CoQ10 may include safeguarding the heart against, stress-related aging. [7] Protecting muscle genetics to keep muscles strong and minimizing bone and joint injury. [8]

5. Cognitive Benefits Of Coenzyme Q10

Oxidative stress is often the root cause behind conditions like Parkinson’s disease and Alzheimer’s. People suffering from such neurodegenerative impairments tend to exhibit lower levels of CoQ10 in their blood. [9]

Brain cells tend to have a higher concentration of mitochondria than most other bodily cells. So without healthy mitochondria concerns like brain fog, impaired mental clarity, forgetfulness and retention issues arise. In this instance, coenzyme Q10 supplementation protects brain cells from oxidative damage and dysfunction. It fuels neuron mitochondria giving the brain the needed boost of energy which helps neural signaling involved in learning, memory, cognition, and recall.

Coenzyme Q10 Benefits

Coenzyme Q10 Benefits

6. Fibromyalgia Symptom Management

While fibromyalgia symptoms can vary immensely from one person to the next, the common denominator remains an acute lack of energy. Studies in this area indicate that mitochondrial dysfunction may be to blame in fibromyalgia which explains the energy deficit experienced by patients.

This is where CoQ10 comes into play. In fact, statistics show that almost 90 % of all cellular energy comes from coenzyme Q10. With fibromyalgia patients, this deficit translates into fatigue, headaches, pain, exercise intolerance, and generalized weakness.

Studies also suggest that mitochondrial dysfunction may be driving an inflammatory response in fibromyalgia patients. [10] However, supplementing with CoQ10 is not a quick fix for fibromyalgia patients. Since every patient is different it can take up to a couple of weeks to restore optimal CoQ10 levels in blood plasma and tissue.

Coenzyme Q10 Side Effects

Taking coenzyme Q10 can present some side effects such as nausea or vomiting but these are typically mild. Some people may also experience diarrhea, heartburn, and loss of appetite. Other may suffer from itchy skin, insomnia, headaches and dizziness.

CoQ10 is also known to lower blood sugar levels and blood pressure and is not recommended for diabetic, hypoglycemic individuals or anyone with low blood pressure.

Coenzyme Q10 Dosage 

CoQ10 is available widely without a prescription. A typical dosage of this supplement ranges between 30 – 90 mg daily taken in two or three smaller doses throughout the day.

That said, for the most part, the dosage is condition-dependant, meaning it’s based on what you’re trying to accomplish. Typical doses can be administered along the following lines. All recommendations are dosages per day.

  • As an antioxidant: 60-150 mg
  • Muscle issues: 300-3,000 mg
  • Recovering from heart attack: 30-600 mg
  • Preventing coronary disease: 200 mg
  • Improving exercise performance: 50-300 mg
  • Chemotherapy side effects: 50-90 mg
  • For fibromyalgia patients, the suggested dosage increases to up to 150-200 mg daily.

These are merely suggested dosage recommendations for coenzyme Q10 supplementation as there is no specific dietary intake recommendation.

Larger dosages up to 1200 mg have been administered but only to study the neurological benefits of CoQ10.

Coenzyme Q10 Considerations 

  • It is recommended to use conventional CoQ10 or ubiquinone with a meal as it is fat soluble and best absorbed when taken with food. Its more advanced form ubiquinol bonds with water making it easier to absorb. This also eliminates the need to take it with fatty foods.
  • All coenzyme Q10 supplements are not created equal. While younger people may benefit from ubiquinone more, older people need more of ubiquinol to meet their health needs.
  • The body uses CoQ10 faster than it can produce it. Therefore, supplementation becomes important.
  • Also, CoQ10 is found in fairly low quantities in even the best food sources so a healthy diet may not be the most practical way to meet the recommended dosages. As such, additional supplementation can help bridge this gap.
  • Coenzyme Q10 works slowly so results may not be noticeable for up to six to eight weeks after stating supplementation.
  • You can also increase coenzyme Q10 supplies by including certain foods in your diet such as chicken, beef, eggs, oily fish, organ meats, peanuts, soybean and canola oils.
Coenzyme Q10 Side Effects

Coenzyme Q10 Side Effects

Coenzyme Q10 Drug Interaction 

There are a number of prescription drugs and over-the-counter medications which can deplete the body of CoQ10. These can include antidepressants, anticonvulsants and analgesic medications.

Statins, which are exceptionally notorious for inhibiting the production of CoQ10 are a standard medication for lowering cholesterol levels.

Coenzyme Q10 Reviews

What are customers & users saying about Coenzyme Q10?

“After 6 Heart Attacks my heart injection rate was at 25% and my doctor was preparing to put me on the heart transplant list. I took 600 mg of the product (CoQ10) daily and after 3 months my injection rate is back to normal since this product restores heart muscle and strength. My Doctors agree that this made a huge effect on my health. There are no side effects from this product. My friends use it to increase their performance in various sporting events.”

“If you’re over 40 and taking coQ10 you’re wasting your money. Your body won’t covert it to the active form that it needs. Ubiquinol is that active version of coQ10 and it’s what you need. This is especially true if you take a statin drug for high cholesterol. Statins wipe out the ubiquinol in your blood. One or two of these a day will raise it back to a pre-40 level. Ubiquinol is also great for anyone who is suffering from bad gums. Make sure you check the ubiquitous 15% discount, it’s almost always available.”

“Great product. It was recommended by my neurologist to help with my migraines.”

“Very effective and economical form of CoQ10, taken with food. I have experimented with several brands and this is my first go with this brand’s softgel formula. I feel it’s the most effective so far. CoQ10 was recommended several years ago by my periodontist and I have had no gum problems since.”

Where To Buy Coenzyme Q10?

If you decided to supplement coenzyme Q10, you can order it here >>

Instead of ordering an individual compound only, I’d suggest getting a more effective and advanced nootropic stack.

In this case, I’d definitely recommend Eternus by Neurohacker.

This is currently the most advanced nootropic stack on the market that also contains a high dose of Coenzyme Q10 (among several other effective nootropics).

Here you can learn more about it >>

P.s. You can use code YOURINCEPTION for 10% discount.


Your Inception Final Recommendation

Your Inception recommends supplementing Coenzyme Q10. 

As you can see, both research and customer reviews about taking coenzyme Q10 holds promising satisfaction.

And while this supplement may not be the cure-all solution for everything, it does seem to help with symptom management of various conditions.

Of course, consulting with your doctor before taking any supplements is a prior must – I would not recommend anything otherwise.

But once you get a medical professional’s go ahead, there seems to be very little reason to not give this helpful and healthful supplement a try.

The trick is to be consistent in usage as it does take its time in showing results.


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By |2019-07-01T10:23:24+00:00May 3rd, 2019|Categories: Nootropics|Tags: |0 Comments

About the Author:

Greg Gostincar is the founder of Your Inception. He has been researching, testing and experimenting with nootropics since 2015. Greg is one of the most recognized researchers in the field of nootropics.

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