Huperzine A Review: 5 Secret Benefits, Dosage & More [RESEARCH] 5/5 (3)

huperzine a review

Huperzine A is extracted from a Chinese club moss (Huperzia Serrata). The extract is purified and offers cognitive enhancement. By inhibiting an enzyme that breaks down acetylcholine, it works as a cholinergic. This property allows it to boost both memory and learning, making it viable for treating Alzheimer’s disease. But should you supplement it? Check out my full Huperzine A review.

Your inception recommends

Increases alertness

Improves memory retention

Fewer side effects than other Alzheimer’s disease solutions

Your Inception does not recommend

It can upset the digestive tract

Slows the heart rate

Huperzine A Review

Huperzine A nootropic is a plant extract with cholinergic properties.

It is extracted from the Chinese club moss and then purified to a point where many consider it a drug and not a dietary supplement.

Huperzine A

Huperzine A

The natives of the land where the plant grows almost always have some inkling of knowledge about its properties.

In this case, the Chinese used the club moss to treat severe mental afflictions like schizophrenia. They also considered it a remedy for fever and inflammation. [1]

Researchers have picked interest in Huperzine A and its nootropic properties. It is no wonder, therefore, that several studies have been conducted to prove and refine its potency and efficacy.

In these studies and clinical trials, the results show that the compound is capable of conferring an enhanced memory.

Alongside this, it also proffers neuroprotective effects on the subject. [2]

But should you give it a try?

How Does It Work?

As a cholinergic, Huperzine A has garnered plenty of interest as a solution in the treatment of dementia resulting from a deficit of acetylcholine-like Alzheimer’s and schizophrenia, among others. [3]

What exactly about this alkaloid is piquing the interest of researchers?

Well, in the case of treating Alzheimer’s disease, the compound works by inhibiting acetylcholine esterase – an enzyme that degrades the neurotransmitter. [4]

This action, however, is reversible.

Through this very mechanism, the alkaloid is also able to block the signaling of Nuclear Factor- kβ.

The result is a reduction in inflammation; hence, the anti-inflammatory properties of Chinese club moss.

Sounds complicated?

huperzine a benefits

Huperzine A Benefits

Huperzine A has many promising positive benefits. Let’s check out the most important ones.

1. Huperzine-A May Prevent Alzheimer’s Disease

Recent studies show that supplementing Huperzine A may not only slow down Alzheimer’s disease but also help to prevent it. [5]

Another study has found that in some patients with Alzheimer’s disease, a clinical trial has shown that huperzine A improves the mental ability of people. [8]

I also found that Huperzine A reduces so-called the NF-kB pathway in the brain cells, which can also help with Alzheimer’s. [9]

2. Huperzine-A Protects The Brain 

Huperzine-A is an NMDA receptor antagonist, so it can help prevent neurons from cell death which happens because of glutamate toxicity. [10]

Besides that, Huperzine A can protect the brain from oxidative damage.

It activates BDNF-depenDENT and mTOR pathways, by which it alleviates oxidative damage from glutamate. [11]

Last but not least, it can protect our brains from oxidative iron damage. [12]

3. Huperzine-A Improves Cognitive Performance

As you probably know, Huperzine A is a popular study supplement. And there is a good reason why.

A study showed that supplementing Huperzine A helped students improve their memory and consequently achieve better results. [13]

That’s what makes it such a popular nootropic.

4. Huperzine-A Promotes Growth of Neural Cells

A study on mice shows that supplementing Huperzine A can stimulate the growth of neuronal cells in the hippocampus of mice. [14]

5. Huperzine-A Helps People With Depressive Disorder (MDD)

Studies also show that Huperzine A can do good as a supporting treatment of cognitive impairment for people with a major depressive disorder (MDD).

Why? Because Acetylcholinesterase (AChE) inhibitors are beneficial when it comes to treating cognitive impairments with people with MDD.

And since Huperzine A is derived from Huperzineserrata, which is, in fact, a potent AChE inhibitor, this makes Huperzine A very effective. [6]

Have you ever heard of a disorder called Myasthenia gravis?

This is an autoimmune disease where the body itself produces antibodies against acetylcholine receptors.

The use of previously mentioned AChe inhibitors can be beneficial. Huperzine A can also help relieve some symptoms of this disease, such as muscle weakness. [7]

Are there any other potential benefits of supplementing Huperzine A?

Yes, there are many, but those that we mentioned have been shown and confirmed through clinical studies.

When new research is done and presented, I’ll include it in this post.

huperzine a dosage

Huperzine A Dosage

Despite the extensive laboratory manipulation resulting in Huperzine A, it is a highly purified compound, and it is considered a dietary supplement in the States.

If you want to improve the memory of adolescents, you need to administer 100 mcg of the Huperzine A supplement twice a day.

On the other hand, if you are combating senility or presenile dementia, administer 30 mcg twice a day.

In the case of using Huperzine A to treat Alzheimer’s disease, the standard Huperzine A dosage can be between 50 to 200 mcg twice daily.

All this is via the oral route, and it does not need one to take with food. This is because the compound is readily absorbed from the stomach into the bloodstream.

Huperzine A is also of interest in the treatment of myasthenia gravis. In such a case, the supplement is given as a shot directly into the muscle.

To avoid Huperzine A overdose, do consult your doctor before supplementing.

huperzine a side effects

Huperzine A Side Effects

As I already mentioned earlier, Huperzine A is a reasonably safe nootropic supplement when compared to others.

However, that is not to say that it does not bring with it a few potential side effects, including:

  • Upset of the gastrointestinal tract
  • Headaches
  • Nausea
  • Slowed heart rate

These are symptoms that are commonplace with continued cholinergic stimulation.

Personally, I’ve been taking Huperzine A as a part of several nootropics in Qualia Mind, and I’ve never experienced any issues.

But it’s still good to be aware of the potential side effects.

Huperzine A Feedbacks And Reviews

Plenty of people have used Huperzine A.

I have collated some of the feedback they had on their experience with the supplement.

“I have been using Huperzine A for about one month. I only take 50 mcg every other day and I have noticed very significant increase in focus, thought process and energy while having no negative effects. I noticed the effect after the first dose and have continued to experience improvement. I believe if you do not notice any changes when taking this product then you don’t have acetylcholine deficiency and do not need it but if you do notice changes then you likely have a deficiency”

“I have used hup A for 2 months taking one capsule per day. I felt my memory had improved considerably and brain fog had lifted. My self-confidence had returned. Then I ran out and have had difficulty finding it in stores. In the meantime I have experienced once again searching for words. I will have to order it online or go out of town to buy since it seems the stores in the area aren’t selling it.”

“I have noticed a somewhat improved cognitive function but also noticed increase in energy”

“It works instantly for me. Probably depends if acetylcholine is the problem. Brain fog vanishes, dreams become vivid, memory improvement, motivation and mood improvement very noticeable on the same day. The downside for me is it makes me so alert I am awake longer at night and it gives me a minor headache so I cut back to every other day so I get those side effects every other day. My mother and grandfather have and had Alzheimer’s and I was feeling very slow tired and foggy as I neared 70 and now I am back to 30 mentally. Worth the side effects.”

So Huperzine A seems quite a promising nootropic, do you agree?

buy huperzine a

Where To Buy Huperzine A?

If you want to order Huperzine A as a single ingredient, I do recommend ordering it here >>

However, I prefer taking most nootropics as a part of a bigger and more effective nootropic stack.

If we are on the same line, then I’d recommend ordering Qualia Mind (read more about it here), which is one of my favorite nootropic stacks.

It contains 50 mcg of Huperzine A 1% extract.

Qualia Mind Experience

You can order Qualia Mind here >>

P.s. Use code YOURINCEPTION & you’ll receive 10% discount.

Your Inception Final Recommendation

Your Inception Guarantee

Your Inception recommends supplementing Huperzine A supplement.

After going through research and scientific evidence presented, Huperzine A nootropic seems a very potent nootropic.

It provides a whole range of benefits, including an increased focus and improved memory retention.

For the maximum effect, combine it with other nootropics as suggested.

It’s recommended consulting your doctor before supplementing.



Frequently Asked Questions

1. How long does a Huperzine A cycle last?
You can use Huperzine A in a cycle that lasts 2 to 4 weeks. This is because the Huperzine half-life lasts from 10 to 14 hours.

2. Do I need to take Huperzine A with food?
Being quite hydrophilic (water-soluble), Huperzine A can cross the barrier from the gastrointestinal tract to the bloodstream. You, therefore, do not need to take it with food so that it can be absorbed.

It’s present in the blood after about 15 minutes, and concentrations therein peak just over an hour after ingestion.

3. Is it safe to take Huperzine A?
Just like with any foreign substance introduced into the body, there is always some side effect. However, Huperzine A is safer than other nootropic supplements used to treat Alzheimer’s disease.

In fact, it is even used in combination with some of these treatments so that a similar positive effect can be achieved without the adverse effects.

4. Is Huperzine a nootropic?
Yes, Huperzine is considered a nootropic. It is used for improving your cognition, memory, and learning. Besides, it is an antioxidant that can help neuroplasticity and have several other benefits.

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By |2019-09-05T12:48:02+00:00October 2nd, 2018|Categories: Nootropics|Tags: , |0 Comments

About the Author:

Greg Gostincar is the founder of Your Inception. He has been researching, testing and experimenting with nootropics since 2015. Greg is one of the most recognized researchers in the field of nootropics.

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