Phosphatidylserine Review: Benefits, Dosage & More
Meet Phosphatidylserine. This phospholipid occurs in the membrane of every cell of your body and brings a lot of pros when it comes to your brain. Assuming this has piqued the interest of your life hacking mind – it definitely did mine – let’s find out more about this nootropic. Here is my full Phosphatidylserine review.
Phosphatidylserine is a protein that is found widely in the membrane of the cells in the body.
This fatty substance is more pronounced in the neural tissue – the brain and the nerves.
While the body synthesizes this compound, you can also take it in as part of your diet. The body absorbs it so well that it even crosses the blood-brain barrier and avails itself for use within your brain tissue.
Studies have shown that phosphatidylserine is very useful in the maintenance and improvement of the health of your neurons. 
Its fatty nature makes it very soluble in the myelin – the sheath that protects the neurons and allows the signals to travel faster along with the nerve cell.
Due to this property, phosphatidylserine nootropic works well to help in the formation and retention of short-term memory. It has also been used in the treatment of Alzheimer’s disease in the elderly. 
Consequently, scientists have tested the efficacy of phosphatidylserine to help those with attention deficit hyperactivity disorder (ADHD).
The compound has given promising results, reducing the attention deficit and hyperactivity in the children tested. 
Phosphatidylserine supplement also reduces stress in individuals without prevailing stress disorders.
Studies, however, find that it doesn’t do this through the usual route of suppressing cortisol or heart rate.
The close interaction with the brain tissue and neurons also render this fatty compound useful in the treatment of depression.
How Does It Work?
Cognitive impairment diseases like Alzheimer’s are usually the result of the degeneration of bunches of your neurons in your brain.
The structural integrity of the nerves steadily deteriorates with age, and they can no longer transfer signals at the appropriate rate. 
This leads to memory loss and other cognitive dysfunction that is usually present in the elderly and children with attention deficit disorders.
Earlier I pointed out that phosphatidylserine is easily absorbed into the blood and readily crosses the blood-brain barrier as well.
When the compound crosses into the realm of the brain neurons, it is easily absorbed by their cell membranes since it is of a very similar lipid structural makeup.
By replacing the lost phospholipids, this compound repairs the structural integrity of the neurons. 
Moods are generally dependent on the number of neurotransmitters present.
As a vital part of the structure of the neurons, phosphatidylserine regulates the number of neurotransmitters released. 
It has a particularly high affinity for dopamine – a neurotransmitter that produces feelings of euphoria and happiness.
Let’s have a look at the main health benefits of phosphatidylserine.
1. Phosphatidylserine Improves Memory
Phosphatidylserine supplement is often taken for improving memory.
There is a lack of studies showing that PS is useful for healthy people.
However, I’ve found a significant study published in Journal of Clinical Biochemistry and Nutrition, which found that people with cognitive impairment who are treated with phosphatidylserine had a significant memory improvement in just six months. 
The memory improvement should be seen in other areas as well, such as faster learning, for example.
2. Phosphatidylserine Helps With Depression And Stress
One of the main reasons why people supplement phosphatidylserine is because it can influence our mood.
There was a study done in 2015 on people with significant depression.
I found that people who were given phosphatidylserine for 12 weeks had their depression decreased and in general felt much better. 
While more studies have to be done, early research seems very promising.
3. Phosphatidylserine And ADHD
Early research shows that supplementing phosphatidylserine can be beneficial for people with ADHD.
There was a study done on 200 children with ADHD.
After a 15-week treatment with phosphatidylserine, researchers have seen a more significant reduction in impulsive behavior and a much better mood in children compared to the placebo. 
Besides those three significant benefits, other studies show phosphatidylserine can be beneficial for improving physical performance, it could help with stress, and much more.
However, more research has to be conducted to confirm all other potential benefits.
To battle Alzheimer’s disease, it is recommended to take a total daily dose of 300 mg to 400 mg of phosphatidylserine nootropic divided throughout the day. 
To stem the onset of age-related mental decline, a dose of 100 mg of the compound three times a day is recommended.
This can last for six months to have the desired effect.
In children and adults who wish to increase their attentiveness, a dose of 200 mg should do the trick.
Phosphatidylserine Side Effects
Seeing as phosphatidylserine is quite widespread in the body, it shouldn’t bring on a large number of adverse reactions.
However, moderation is important.
You should, therefore, follow the recommended dosages to ensure that you only get the advantageous effects.
The common side effects include:
Gas and bloating
Back in the day, phosphatidylserine was mainly made from cattle.
The protein was extracted from the cortex of the brains of cattle. This was risky because one could easily acquire the human form of mad cow disease – Creutzfeldt-Jakob disease.
However, phosphatidylserine is now gotten from plant sources like soy, which don’t put you at risk of this neurodegenerative disease.
There’s generally good feedback from people who have used phosphatidylserine.
“I was given a bottle for my dad in late stages of Alzheimer’s and it was too late … he had so many other pills to swallow we had to choose to eliminate this one since we did not see its effectiveness. BUT! I started taking it and noticed tremendous improvement in cognitive ability especially as a pianist … my clarity and quickness improved my playing noticeably.”
“This supplement virtually saved my life. I take ADD medicine, but only after taking Phosphatidylserine was I able to fully take control of my emotions. I was able to move away from being hyper vigilant. My startle reflex slowed down to a manageable level. I remember after about 2 months I thought to myself? This is what normal feels like? I have been taking PS for 10 years now. I was able to complete a Master’s in Business Administration and earn several professional certifications. I can’t explain how or why, but I’m very thankful for the result. This is only part of the results.”
“I had a MVA and suffered a close skull concussion with word finding difficulties and short term memory loss. I had tried many other products with no relief now I use PRO CAP LABS product 200 mg. once a day from Andrew Lessmam and have had a HUGE improvement in both problems. Worth a try for memory problems in my opinion.”
“I have Depression, ADHD and have mitochondria fatigue problems. Have tried huge amount of different supplements over the last years and PS is one of the very few that helped noticeable. I started 4 months ago with 100mg and was somewhat dizzy and confused after first dose. Decided then to take it in the evening and upgraded dose up to 300mg in a few weeks. Sleep has improved massively. I’m relaxed and enjoyable in daily life and can work as scientist again. Stopped a few days and yeah I realized the difference. My anxiety and agitation have improved! In combination with high doses of methylcobalamine, very small dose of methylphenidat and duloxetin I feel healthy and can do competitive sports.”
Where To Buy Phosphatidylserine?
If you’ve decided to order phosphatidylserine, you can do it here.
As you’ll see, you have different options available, so choose the best for yourself.
However, I would suggest getting phosphatidylserine with other effective nootropics and supplements.
That’s the only way to ensure optimal cognitive performance.
My suggestion is to go for Mind Lab Pro, the most popular and effective nootropic stack on the market.
Mind Lab Pro
Mind Lab Pro contains some of the most effective nootropics, and it can provide a whole range of benefits, including better focus, memory, clarity, and overall productivity.
1. What does phosphatidylserine do? Phosphatidylserine is useful in the treatment of Alzheimer’s disease. It is also used to improve memory and cognitive function. This is seen when it is used in individuals who have attention deficit hyperactivity disorder (ADHD).
2. Is it safe taking phosphatidylserine? It’s pretty safe to take phosphatidylserine. It does not give you any real adverse side effects. However, you might experience some insomnia and stomach upsets.
3. What is the half-life of phosphatidylserine? The half-life of phosphatidylserine is about 8 hours in animals. The exact half-life for humans has not been established yet.
Greg Gostincar is the founder of Your Inception. He has been researching, testing and experimenting with nootropics since 2015. Greg is one of the most recognized researchers in the field of nootropics.