PQQ Review: 9 Benefits, Side Effects, Dosage [And More] 4.75/5 (4)

pqq review

A somewhat recent entrant to the world of nootropics, PQQ or pyrroloquinoline quinone, joins the ranks of smart drugs in neuroscience. It is a small molecule that was once believed to be a vitamin, but its functions establish it as a cofactor instead. Other than its designation as a nootropic, researchers also categorize it as a dietary supplement that can do much more than boosting your brainpower. But does it really work? Check out my full PQQ review.

Your inception recommends

Offers cognitive benefits

Reduces oxidative stress

Lowers inflammation

Your Inception does not recommend

May cause headaches and dizziness

High dosage can be toxic

PQQ Review

If this is the first time that you hear about pyrroloquinoline quinone (PQQ), you may have a lot of questions about its claims and potential.

Well, that’s where I come in to help you out. In this article, I will look at the evidence that supports PQQ’s health claims and what this vital compound can do for your health.

Although it may have earned its nootropic designation fairly recently, PQQ has been around for a long time. This micronutrient was discovered about 20 years ago as a redox cofactor. These are chemical compounds required for an enzyme’s activity.

It is found naturally in soil, certain foods, human breast milk as well as in tissues and bodily fluids.

PQQ in foods

PQQ can be found in different foods such as:

  • Parsley
  • Green peppers
  • Papaya
  • Oolong and green tea
  • Natto (fermented soy)
  • Eggs & Dairy

As research on PQQ continued, its ability to decrease mitochondrial dysfunction and stimulate mitochondrial biogenesis started becoming significant.

And since there is a significant number of mitochondria in the brain, researchers started investigating its effects on cognitive functioning.

The cofactor has received a lot of attention in Japan, where it has often been compared to CoQ10 for its effects on healthy elderly patients with cognitive decline.

The two have also been paired together to see if these benefits can be multiplied.

In fact, neurohackers report dramatic improvements in mental and physical energy when adding PQQ to their nootropic stack. Adding in CoQ10 can multiply the synergistic effect.

PQQ Supplement 

pqq supplement

The primary area where PQQ stands out is its effect on mitochondria. These are parts of the cell that generate the energy cells need to survive.

Mitochondria do so by converting food intake and oxygen into clean energy. But because of their constant exposure to high levels of energy and oxygen, mitochondria are highly susceptible to damage by oxidative stress.

With time, they start to lose their capability to manage the energy transfer effectively.

As a person ages, the mitochondria begin to malfunction or develop defects. This damage may be structural or functional.

This dysfunction can then result in brain fog, impaired memory and recall, and cognition problems. When this progresses unchecked, the risk of neurodegenerative diseases like Parkinson’s, Alzheimer’s, Huntington’s, and stroke rises.

Such oxidative mitochondrial decay is now recognized as a significant contributor to aging.

Research shows that PQQ helps generate new mitochondria in brain cells. [1]

In fact, it is the first micronutrient discovered that can do so. Also known as mitochondrial biogenesis, increasing the number of mitochondria can lead to a host of anti-aging benefits, not restricted to the brain alone. [2]

Cells with new mitochondria will have the energy they need to work optimally all over the body.

PQQ Benefits

PQQ can offer some impressive benefits when it comes to boosting energy levels, preventing disease, reducing oxidative stress, and even helping you sleep better.

It even possesses an antioxidant potential that can impact areas of overall health regarding inflammation, cholesterol levels, and anti-aging.

Here are the most prominent benefits you can hope to reap when you include PQQ supplementation into your daily diet.

pqq benefits


  • Promotes NGF Production
  • Reduces Oxidative Stress
  • Relieves Inflammation
  • Prevents Glucose-induced Brain Damage
  • Lowers Cholesterol
  • Promotes Heart Health
  • May Promote Ischemic Stroke Recovery
  • May Improve Immunity
  • Improves Sleep

Let’s check them more in details.


Loss of brain function brings about cognitive decline, memory loss, and a slow deterioration of the self.

In fact, the brain seems to be a major target of mitochondrial aging. PQQ appears to be effective in many of these areas and present some robust effects against brain aging.

1. PQQ Promotes NGF Production

The nerve growth factor is a protein necessary for the growth of some parts of the nervous system, including the neurons. It is responsible for the development of new neurons and for the health and maintenance of mature ones.

Research shows that NGF triggers the growth and branching of nerve cells. It also affects neuroplasticity or the way brain cells make connections and communicate with one other.

Animal testing reveals that as the production of NGF decreases in the brain, the ability to form new connections, retention and recall are all impaired.
By stimulating NGF production, PQQ helps protect memory as well as cognition.

2. PQQ Reduces Oxidative Stress

PQQ possesses antioxidant features which can help protect cells from oxidative stress and damage. Multiple studies in this area confirm this. [3] [4]

Animal studies show that gains in memory and learning ability were observed in rats supplemented with PQQ. Much of this improvement was due to PQQ’s potential to limit oxidative damage. [5]

Oxidative damage happens to be a primary factor contributing to neurodegenerative diseases. Research shows that when PQQ is present, cells susceptible to oxidative damage are shielded from death and DNA fragmentation.

This possibility makes PQQ of particular concern in treating neurodegenerative diseases like Parkinson’s and Alzheimer’s.

However, it can do so much more than just ward off free radical damage. It has unique characteristics that allow it to catalyze specific body reactions to a much greater extent than the best-known antioxidants.

For instance, PQQ can carry out a lot more catalytic conversions as compared to vitamin C, which can carry out a total of four.

3. PQQ Relieves Inflammation

At the same time, PQQ’s antioxidant properties may also help reduce inflammation. One study looked at its effects on inflammatory markers. [6]

This study involved human subjects who were given a fruit-flavored beverage supplemented with PQQ. Findings of the study showed that there was a reduction in inflammatory markers after three days.

Neuroinflammation is inflammation occurring in the brain. It degrades brain cells directly and speeds up the process of aging.
In the case of neurodegenerative diseases, chronic low-grade inflammation is present in the brain.

The same can also occur after a traumatic brain injury or stroke.

PQQ works to counter this by preventing the production of beta-amyloid and alpha-synuclein. [7]

These are these pro-inflammatory markers that can cause widespread brain cell death and impair normal brain functioning. But PQQ can intervene and result in fewer brain cell deaths and preserve brain function as well.

By preventing neuroinflammation, PQQ can safeguard against the aftermath caused by traumatic brain injury.

4. PQQ Prevents Glucose-induced Brain Damage

Another neuroprotective feature of PQQ is its ability to protect the brain from harm caused by high blood sugar. Now, this may seem a little odd, but a consequence of diabetes is cellular damage in the brain.

This happens when brain cells are exposed to chronically high levels of blood sugar. Diabetic individuals are at a 60% greater susceptibility to developing dementia.

Plus, high levels of insulin in diabetes can also factor in neurological damage.

Research shows that when brain cells were exposed to elevated blood sugar levels in vitro, the result was high cell mortality.

But when PQQ got added into the mix, it not only reversed the damage but also suppressed cellular death. And it limited the production of reactive species. [8]


The remarkable benefits of PQQ are not restricted to cognitive perks alone but can also add to the vitality of the heart and the immune system.

pyrroloquinoline quinone benefits

5. PQQ Lowers Cholesterol

Although still preliminary, some research indicates that PQQ could also hold the potential to reduce cholesterol levels.

One study that worked with 29 healthy individuals with normal to moderately high triglyceride levels shows some promising results.

Participants were given an oral dosage of 20 mg daily for 6 and then 12 weeks. After 6 weeks results showed that participants with elevated LDL cholesterol levels had undergone a significant decrease in total cholesterol and LDL cholesterol with results persisting at 12 weeks. [9]

6. PQQ Promotes Heart Health

The heart is an organ that is continuously in action. It pumps 24/7 and needs a constant supply of energy to do so.

Once again, PPQ’s mitochondrial generating properties come into play that supports cardiovascular health.

The two facets of PQQ performance of supporting healthy mitochondrial and energy production help keep your heart running at optimal performance.

7. PQQ May Promote Ischemic Stroke Recovery

An ischemic stroke occurs when there is a loss of blood to a specific area of the brain. This deprives the brain of the oxygen and essential nutrients it needs.

Deprivation results in the death of brain cells and loss of function in the affected area. Depending on what part of the brain gets affected, an ischemic stroke may result in paralysis, memory impairment, and in worst cases, death.

Animal model studies show PQQ reducing ischemic damage. Subjects that were given PQQ supplementation before ischemia was induced had reduced brain tissue damage.

When administered after the stroke, it still offered protective effects.

8. PQQ May Improve Immunity

Immune system cells rely heavily on PQQ for normal functioning. This becomes especially important for older demographics whose immunity can become compromised with age.

Any deficiency of PQQ can produce defects in different areas of the immune system.

But supplementing with 1-4 mg of PQQ supplement can maximize the sensitivity of B and T lymphocytes and improve immunity.

9. PQQ Improves Sleep

Some limited research also suggests that PQQ may well be beneficial for promoting better quality sleep.

One study points to reducing symptoms of daytime fatigue and improving sleep duration after supplementation.

Participants of this study also experienced a reduction in the time it took to fall asleep and how alert they felt in the morning. [10]


PQQ and COQ10 are often bundled together for maximum potency, even though they work via distinctly different mechanisms.

CoQ10, for instance, is necessary for mitochondrial function, and any abnormal production may lead to several health problems.

PQQ, on the other hand, is not essential to mitochondrial function but does increase the number of mitochondria in cells.

When taken together, one makes new mitochondria while the other helps the mitochondria do its job right.

Both are needed by energy-intensive organs like the heart, brain, muscles, and kidneys.

pqq dosage

PQQ Dosage

There is no set dosage for PQQ as yet, but based on clinical studies, PQQ supplement seems to be effective in low doses.

For instance, it may even be effective in doses as low as 2 mg daily.

However, supplements available commercially are marketed in 20, 30, and 40 mg strengths. These seem to be safely tolerated by most people. It is best to start at the lower end of the spectrum and work your way up gauging tolerance.

Supplements are manufactured synthetically with only one formulation produced naturally.

It goes by the name for BioPQQ® by Mitsubishi Gas Chemical Company of Japan and is produced using bacterial fermentation.

This formulation is then licensed to different supplement makers.

Various synthetic forms of PQQ are manufactured via chemical synthesis with undetermined safety issues.

PQQ Side Effects

The most common side effects of taking PQQ supplementation include drowsiness, headaches, and fatigue.

However, PQQ can present some severe side effects if the dosage exceeds. A high dosage is considered dangerous and toxic.

Therefore, I recommend starting with a low dosage and consulting your doctor before that.

pyrroloquinoline quinone buy

Where To Buy PQQ? 

If you want to order PQQ, I’d suggest buying Mind Lab Energy, one of the most advanced and effective supplements for improving the energy that contains 10 mg of PQQ.

You can read more about it here >>

To get the LOWEST price, click here >>

Your Inception Final Recommendation

Your Inception Guarantee

Your Inception recommends supplementing pyrroloquinoline quinone.

From reading this article, you’ll know that loss of mitochondrial function is both a cause and consequence of aging.

As an alternative solution, PQQ offers a potent strategy to combat brain aging. I feel that as a nootropic, PQQ holds immense potential in different areas of cognitive health.

The only, if any limitation, is that the bulk of the scientific studies have been done on animal subjects with very few involving human participants.

So if you’re solely looking for evidence-based confirmation backed by large scale studies, you may find yourself a little skeptical using this supplement.

Otherwise, this supplement seems to show tremendous promise at fighting age-related brain dysfunction.




1. Is PQQ dangerous?
No, PQQ is not dangerous. Current studies show that PQQ is a very beneficial nootropic that can provide a whole range of benefits. However, the lack of it might be dangerous.

2. Is PQQ a nootropic?
Yes, PQQ is a nootropic and a very potent antioxidant. It plays a vital role in improving cognition, that’s why it is often added to popular nootropic stacks.

3. Does PQQ cross the blood-brain barrier?
No, it seems that PQQ does not cross the blood-brain barrier. That is why it is combined with other nootropics and supplements that can cross it.

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By |2019-08-22T08:26:31+00:00May 15th, 2019|Categories: Nootropics|Tags: , |0 Comments

About the Author:

Greg Gostincar is the founder of Your Inception. He has been researching, testing and experimenting with nootropics since 2015. Greg is one of the most recognized researchers in the field of nootropics.

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