3. PQQ Benefits
PQQ can offer some impressive benefits when it comes to boosting energy levels, preventing disease, reducing oxidative stress and even helping you sleep better. It even possesses an antioxidant potential that can impact areas of overall health regarding inflammation, cholesterol levels, and anti-aging.
Here are the most prominent benefits you can hope to reap when you include PQQ supplementation into your daily diet.
Loss of brain function brings about cognitive decline, memory loss and a slow deterioration of the self. In fact, the brain seems to be a major target of mitochondrial aging. PQQ seems to be effective in many of these areas and present some robust effects against brain aging.
1. PQQ Promotes NGF Production
The nerve growth factor is a protein important for the growth of some parts of the nervous system including the neurons. It is responsible for the development of new neurons and for the health and maintenance of mature ones.
Research shows that NGF triggers the growth and branching of nerve cells. It also has an effect on neuroplasticity or the way brain cells make connections and communicate with one other.
Animal testing reveals that as the production of NGF decreases in the brain the ability to form new connections, retention and recall are all impaired. By stimulating NGF production, PQQ is helpful for protecting memory as well as cognition.
2. PQQ Reduces Oxidative Stress
PQQ possesses antioxidant features which can help protect cells from oxidative stress and damage. Multiple studies in this area confirm this.   Animal studies show that gains in memory and learning ability were observed in rats supplemented with PQQ. Much of this improvement was due to PQQ’s potential to limit oxidative damage. 
Oxidative damage happens to be a primary factor contributing to neurodegenerative diseases. Research shows that when PQQ is present, cells susceptible to oxidative damage are shielded from death and DNA fragmentation. This possibility makes PQQ of particular concern in treating neurodegenerative diseases like Parkinson’s and Alzheimer’s.
However, it can do so much more than just ward off free radical damage. It has unique characteristics that allow it to catalyze certain body reactions to a much greater extent than the best-known antioxidants. For instance, PQQ can carry out a lot more catalytic conversions as compared to vitamin C which can carry out a total of four.
3. PQQ Relieves Inflammation
At the same time, PQQ’s antioxidant properties may also be helpful for reducing inflammation. One study, in particular, looked at its effects on inflammatory markers.  This study involved human subjects who were given a fruit flavored beverage supplemented with PQQ. Findings of the study showed that there was a reduction in inflammatory markers after 3 days.
Neuroinflammation is inflammation occurring in the brain. It degrades brain cells directly and speeds up the process of aging. In the case of neurodegenerative diseases, chronic low-grade inflammation is present in the brain. The same can also occur after a traumatic brain injury or stroke.
PQQ works to counter this by preventing the production of beta-amyloid and alpha-synuclein.  These are these pro-inflammatory markers that can cause widespread brain cell death and impair normal brain functioning. But PQQ can intervene and result in fewer brain cell deaths and preserve brain function as well.
By preventing neuroinflammation, PQQ is able to safeguard against the aftermath caused by traumatic brain injury.
4. PQQ Prevents Glucose-induced Brain Damage
Another neuroprotective feature of PQQ is its ability to protect the brain from harm caused by high blood sugar. Now, this may seem a little odd, but a consequence of diabetes is cellular damage in the brain. This happens when brain cells are exposed to chronically high levels of blood sugar. In fact, diabetic individuals are at a 60% greater susceptibility to developing dementia. Plus, high levels of insulin in diabetes can also factor in neurological damage.
Research shows that when brain cells were exposed to elevated blood sugar levels in vitro, the result was high cell mortality. But when PQQ got added into the mix, it not only reversed the damage but also suppressed cellular death. And it limited the production of reactive species. 
The remarkable benefits of PQQ are not restricted to cognitive perks alone but can also add to the vitality of the heart and the immune system.
5. PQQ Lowers Cholesterol
Although still preliminary, some research indicates that PQQ could also hold the potential to reduce cholesterol levels. One study that worked with 29 healthy individuals with normal to moderately high triglyceride levels shows some promising results. Participants were given an oral dosage of 20 mg daily for 6 and then 12 weeks. After 6 weeks results showed that participants with elevated LDL cholesterol levels had undergone a significant decrease in total cholesterol and LDL cholesterol with results persisting at 12 weeks. 
6. PQQ Promotes Heart Health
The heart is an organ that is constantly in action. It pumps 24/7 and needs a constant supply of energy to do so. Once again, PPQ’s mitochondrial generating properties come into play that supports cardiovascular health. The two facets of PQQ performance of supporting healthy mitochondrial and energy production help keep your heart running at optimal performance.
7. PQQ May Promote Ischemic Stroke Recovery
An ischemic stroke occurs when there is a loss of blood to a specific area of the brain. This deprives the brain of the oxygen and essential nutrients it needs. This deprivation results in the death of brain cells and loss of function in the affected area. Depending on what part of the brain gets affected, an ischemic stroke may result in paralysis, memory impairment and in worst cases, death.
Animal model studies show PQQ reducing ischemic damage. Subjects given PQQ supplementation before ischemia was induced showed reduced brain tissue damage. And when administered after the stroke, it still offered protective effects.
8. PQQ May Improve Immunity
Immune system cells rely heavily on PQQ for normal functioning. This becomes especially important for older demographics whose immunity can become compromised with age. Any deficiency of PQQ can produce defects in different areas of the immune system. But supplementing with 1-4 mg of PQQ can maximize the sensitivity of B and T lymphocytes and improve immunity.
9. PQQ Improves Sleep
Some limited research also suggests that PQQ may well be beneficial for promoting better quality sleep. One study points to reducing symptoms of daytime fatigue and improving sleep duration after supplementation. Participants of this study also experienced a reduction in the time it took to fall asleep and how alert they felt in the morning. 
PQQ Side Effects