With a name that sounds like something straight out of a biology textbook, it is no surprise that uridine monophosphate (UMP) needs a bit of a biological introduction.
Also called uridine 5 monophosphate is a chemical compound found primarily in the nucleus of a cell. It is one of the five nucleosides that make up a nucleic acid.
The nucleic acid is an important part of RNA which is a fundamental part of the cell structure of the nucleus.
But without getting too scientific about it, the basics tell us that uridine monophosphate is one of the basic components found in RNA.
RNA is the messenger responsible for carrying instructions for DNA, without which life would not be possible.
Now, DNA is the genetic code of all living things with instructions for growth, development, and functioning.
It is structured as a double helix of which RNA is a major component. And one of the major components of RNA is uridine monophosphate responsible for many important functions.
Uridine monophosphate also goes by the name of 5’-uridylic acid and is essential for the healthy functioning of the central nervous system. This is also the area where UMP yields its cognitive benefits.
Although uridine is present in many different foods, simply eating these foods cannot elevate uridine levels in the brain.
A high percentage of dietary uridine gets absorbed in the digestive system and only a relatively small portion makes it to the brain.
It is the monophosphate content of uridine that acts as a transporter and allows uridine to cross the blood-brain barrier, reach the brain, and yield its benefits there.
As such, the nootropic benefits are only realized when it is supplemented as UMP rather than form food sources alone. Its ability to go across the blood-brain barrier makes it way more bioavailable when compared with other uridine forms.
As such, uridine monophosphate supplements are a more popular option to procure cognitive and other benefits.
Uridine Monophosphate Benefits
As uridine gets absorbed in the bloodstream, it can readily exert its nootropic effects in the following ways:
Uridine Monophosphate Benefits
1. Improves Memory
Just as with anything else, uridine levels also decline with age. This has a direct effect on cognition, memory, and recalls with brain cell membranes degenerating, neurotransmitter levels declining, taking neural and synaptic activity with them.
That said, memory is dependent to a large degree on neuroplasticity, or the brain’s ability to learn and form memories.
The process of turning experiences into memories depends on neurogenesis or the formation of new neurons.
The ability to think, deduce, and remember results from innumerable neurons and synapses connected together.
Here uridine, in collaboration with DHA and choline, works to increase synapse density by encouraging the formation of neurons. 
Uridine, upon reaching the brain, enhances CDP-choline which is used for phosphatidylcholine synthesis. This process results in acetylcholine production which is a crucial neurotransmitter.
When you add more uridine to the diet, it encourages the production of phospholipids through CDP-choline.
Now phospholipids are needed to encase fresh neurons upon formation. So, by promoting the growth of synapses, neurons, and neuroplasticity, uridine acts as a boost for cognitive performance.
The same also has the effect of increasing alertness and focus on individuals who may experience problems in these areas.
And while neuroplasticity is essential to all aspects of cognition, it has a particularly significant effect on memory.
Any loss can result in impaired cognition while increased neuroplasticity can become an important part of treating age-related conditions like Alzheimer’s.
2. Neuroprotective Features
Uridine monophosphate offers many neuroprotective features. Apart from the obvious part, it plays in neurogenesis and synaptogenesis, UMP offers neuroprotection that is multilevel.
For starters, it protects the myelin sheath. Myelin is an important part of the central nervous system and crucial for optimal cognitive functioning.
The myelin sheath is a cover made of fats and proteins that insulates neurons enabling them to send signals faster and more efficiently.
Cells known as Schwann cells produce the myelin sheath and any damage to these cells slows down neural communication.
Here, uridine protects the neuronal covering and helps treat any myelin sheath lesions. 
In addition, uridine can prevent fatty acid accumulation around neurons. If these acids start to collect in the brain, they can increase inflammatory responses.
They can also trigger free radical damage causing neural membrane breakdown.
Since uridine promotes neurotransmitter release, it can improve neural coordination.
It can help put the brain in a constant state of activity preventing decline from disuse. It can also inhibit oxidative stress by scavenging free radicals and fighting inflammatory responses.
3. Activates Nerve Growth Factor
Nerve growth factor (NGF) is a protein important for the maintenance, survival, and growth of nerve cells including brain cells.
By optimizing the amount of NGF present, the body can upgrade its neural network and create stronger more abundant synaptic connections.
This, in turn, can help improve brain function including memory and cognition.
Uridine monophosphate has been known to promote neuronal growth by activating NGF through TrkA receptors. 
4. Improves Mood
Uridine also stimulates the release of the feel-good neurotransmitter dopamine in the brain. This is the chemical messenger responsible for sending signals to the brain.
The same is also involved in the sensations of reward and motivation.
A dopamine deficiency can often be the reason behind a lack of motivation, anxiousness, and lethargy among other things. And to help regulate or stabilize the mood, uridine might be the missing component here.
Since uridine improves the production of dopamine, it can counter mood swings common in depressed patients.
Uridine can also successfully ward off stress by lowering the damaging effects of cortisol. 
The brain, being the sole organ for determining stress response, acts based on how much cortisol gets released.
However, cortisol can only be beneficial when it responds to acute stressors. But chronically high levels of cortisol only aggravate stress and increase the chance for depression instead.
In such cases, supplementing with uridine monophosphate can help counter that effect by promoting dopamine production.
Uridine gets transformed into a phospholipid in the brain and phospholipids are known to reduce the negative effects of cortisol. 
5. Reduces Depressive Symptoms
This mood-enhancing and especially depression-reducing facet of UMP is observed most when uridine monophosphate is stacked alongside omega 3 fatty acids such as DHA.
The antidepressant effects of omega 3s have already been established by extensive research. Uridine also seems to present a similar effect and a combination of the two was found to be effective at lower doses of each.
Researchers believe that depression is caused in part by an imbalance of neurotransmitters.
When uridine is paired with omega 3s, its effects are felt by changing fats in the brain. Their cumulative effect seems to make membranes more resilient that helps ease the flow of neurotransmitters.
In a highly cited 2011 study, uridine supplementation was seen to be effective for depression occurring in combination with bipolar disorder. 
6. Anti-inflammatory Potential
The ability of uridine to attenuate inflammation is a protective function that extends beyond the brain. Not only is it beneficial to the brain but other body tissues as well. 
Typically, inflammation results from a direct reaction to tissue damage at a cellular level. This is actually a good thing for it is an attempt to repair the damage done and is beneficial in the short-term.
However, when inflammation becomes extended and persistent in the body, it brings about not only muscle damage but a number of other conditions as well.
Uridine acts as a leukocyte-adhesion inhibitor, a key factor in inflammatory responses. 
In one area, uridine’s anti-inflammatory effects were observed in carpal tunnel patients.
Participants received treatment using a combination of uridine, folic acid and vitamin b12 with results showing reduced pain and associated symptoms. 
Stacking Uridine Monophosphate
Stacking uridine with DHA and choline seems to present the greatest benefits.
As mentioned previously, DHA and UMP work well together to reduce depressive symptoms. At the same time, throwing in choline into the mix causes the brain to produce more synapses. 
Synapses are key to brain function, so the more there are, the better the brain works.
For optimal results, experts recommend stacking UMP with omega 3s that include at least 700mg DHA and 300mg EPA.
Pair up your UMP supplementation with a good choline source between 50 mg of alpha GPC or CDP choline. You can then increase your dose based on response to 300 mg.
Luckily, there are a few amazing nootropic stacks available on the market that have a great combo of all mentioned nootropics.
I’ll share more information with you below.
Uridine Monophosphate Dosage
UMP is generally considered safe and effective when taken in doses between 500 and 1,000 mg daily.
Uridine Monophosphate Dosage
Since it is produced naturally in the body, it is considered safe and well-tolerated by most.
Many neurohackers consider uridine most effective when it is taken alongside other supplements, especially choline, DHA, folate and vitamin B12.
It is alright to take uridine either with or without food. When compared to other nootropics, UMP does take a while before yielding effects, but this can be amplified by stacking it with other supplements.
The best recommendation is to start between 150 to 250 mg twice daily and then scale upwards to determine the most optimal dose.
Uridine Monophosphate Side Effects
When taken as recommended, uridine supplementation rarely presents any side effects.
The most common complaints include experiencing headaches, nausea, nervousness and perhaps some fatigue.
Exceeding the recommended dosage may, however, present unpleasant symptoms like diarrhea and fever.
These will stop once the dosage is lowered.
I recommend consulting your doctor before supplementing uridine monophosphate.
Uridine Monophosphate Reviews
So, what do people who supplement uridine monophosphate say about it?
“It works especially when you take it with DHA and Vitamin B. You NEED folate or vitamin B when you take these, you can read more on why online. But they make you more balanced mentally I think they worked great in stabilizing the dopamine receptors.”
“Uridine saved me! I had a lot of neural symptoms after being seriously ill and going through some extreme stress. There was no way to put it. But uridine did! Better sleep better mood, better memory, better concentration, diminished anxiety and depression. There is an immediate boost but the real benefits came after a few weeks. I’m hooked on this supplement!”
Where To Buy Uridine Monophosphate?
UMP is available in both powder and capsule form.
If you want to buy it as an individual compound, you can buy it here >>
However, it’s recommended taking uridine monophosphate with other compounds such as vitamin b12, choline, DHA, etc.
That’s why I’d recommend buying an advanced nootropic stack that contains all mentioned nootropics including more than 20 others.
If you are serious about hacking your cognitive performance, Qualia Mind is a perfect product for you.
You can read more about it here >>
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