Ultimate Guide to Adrafinil (Review, Dosage, Side Effects & More) 5/5 (7)

Adrafinil Review

Earlier this year I wrote an article on Modafinil. Now it’s time for a history lesson and get to know its predecessor Adrafinil, which packs just as big of a punch as the “Limitless pill” itself.

Improves alertness, wakefulness, and mood

Reduces fatigue

Improves cognitive performance and memory

Potential headaches, elevated blood pressure and stomach problems

Potential effect on the liver

What is Adrafinil?

Adrafinil, also known by its brand name Olmifon, is a smart drug used to improve alertness, wakefulness, and mood.

It was discovered in France in the 1970s and is most commonly used by people who work in the early mornings or those who work the graveyard shift.

Adrafinil works in two ways:

  • It helps boost the production of the neurotransmitter hypocretin, which is responsible for wakefulness. Kick your dosage up to a notch, and Adrafinil will also reduce fatigue.
  • Second, this focus-boosting drug improves cognitive performance and memory by breaking down Glutamate, the most abundant neurotransmitter in the human body.

After a few years of trial and error, scientists found out that Adrafinil is in fact, a prodrug to the more famous Modafinil. A prodrug is a chemical substance which, once consumed, gets broken down by the body’s metabolism into metabolites. In this instance, Adrafinil gets metabolized into modafinil.

Should you consider taking Adrafinil? Let’s check out more.

Adrafinil vs. Modafinil

As you already read, Adrafinil is a precursor of Modafinil. Both substances were developed to treat narcolepsy, idiopathic hypersomnia, and to enhance the mental functioning of the elderly. Since one is basically a father to the other, the two wakefulness promoting compounds have pretty similar effects.

Modafinil seems to be the more potent of the two, as Olmifon was taken out of circulation in 2011 by Cephalon, a French pharmaceutical company that bought out Laboratoires Lafon, the company that discovered Adrafinil in 1974.

Adrafinil Vs Modafinil

Adrafinil Vs Modafinil

Adrafinil is predominantly a cerebral stimulant. This means this smart drug will give your mental abilities a boost but will have little carryover to your motor coordination, unlike some other stimulants. A higher level in hypocretin causes a spike in dopamine, norepinephrine, and histamine, leading to better alertness and focus, making it a very good study drug.

Modafinil, since it is a metabolite, will have pretty much the same effects on our productivity as Adrafinil, but it gets absorbed into our body almost twice as fast. Adrafinil needs to first be broken down in the liver, so it usually takes 45-60 minutes to kick in as opposed to Modafinil, which only needs about 25-40 minutes.

If you’re an athlete, both Adrafinil and Modafinil are on the WADA banned substance list since 2004.

But if you’re in the armed forces, many countries prefer Modafinil over amphetamines for soldiers in combat situations or long missions.

Adrafinil Dosage

Adrafinil is most effective when taken in doses between 300 and 1200 mg.

If you don’t have your own scale yet, this is the time to buy it.



Adrafinil is a smart drug that brings some baggage with it, so taking it may result in some side effects. If you decide to buy Adrafinil in powder form, buy a scale and weigh your doses precisely to avoid as many of the side effects I will write below as possible. Start out at the lower end and gradually work your way up (if needed) to taking 1200 mg.

It is water soluble, so you can mix it into water or juice and drink it on an empty stomach to get the best results.

It is best to take it early in the morning, as some users have reported having trouble falling asleep if they’ve taken Adrafinil too late in the day.

Because it may take a toll on your liver, Adrafinil is best used sparsely or in cycles at the most. If you decide to cycle it, I recommend you take a week off for every two weeks of taking this smart drug.

Taking Adrafinil long term may result in developing tolerance against the drug, so you’ll have to take more and more to achieve the same results.

Adrafinil Side Effects

As with taking any other smart drug, please practice caution.

Adrafinil is a great smart drug for those who need an occasional boost when working long hours or crazy odd shifts. Taking it on a regular basis is highly discouraged.

Adrafinil Side Effects

Adrafinil Side Effects

Side effects of Adrafinil are quite similar to those of Modafinil. These include headaches, elevated blood pressure, nausea, and stomach problems. It may cause daydreaming or even hallucinations.

It is also reported that Adrafinil is a mild appetite suppressant, which can be a good or a bad thing.

I’ll let you be the judge.

One last thing that needs to be addressed is Adrafinil’s effect on the liver.

Adrafinil has been proven to increase liver enzymes because it needs to be metabolized in the liver before it actually begins to work. While increased liver enzymes by themselves might not be a health risk, this may have a trickle-down effect on any other medical issues you might have, so bear this in mind.

So, before supplementing Adrafinil, I would highly recommend consulting your doctor!

How to Stack Adrafinil?

As with many other cognitive enhancers, there are a few nootropics on the market that have a synergistic effect on adrafinil and make it even more potent. If you’re trying to squeeze the most out of your adrafinil or are looking to improve your own nootropic stack, keep reading!

Stack Adrafinil

Stack Adrafinil

It is a powerful nootropic, known for its memory boosting characteristics. Pramiracetam will increase the production of choline, which is then transformed into acetylcholine, a key neurotransmitter in cognitive processes such as memory, concentration, and learning speed.

Combining 100 mg of pramiracetam with Adrafinil will result in an energy and memory boost without the jitters that some other stimulants might induce.

Alpha GPC is another cognitive enhancer very dear to me. It works very similar to Pramiracetam in the sense of raising the body’s choline levels, resulting in more focused and better study/work sessions.

It is quite common for Alpha GPC users to combine it with Pramiracetam to max out their focus and learning speed. For starters, combine 300 mg of Alpha GPC it with Adrafinil and you will be alert and ready for intense mental work.

L-Theanine is an amino acid, commonly found in tea leaves will undoubtedly benefit Adrafinil users. Many use Adrafinil when facing strict deadlines, which means they will be operating at high-stress levels. Recent studies show L-Theanine promotes relaxation and fights fatigue without inducing drowsiness.

Stacking Adrafinil with about 50 mg of L-Theanine will enable users to stay focused and up for longer periods of time while reducing anxiety levels brought up by their demanding tasks.

It is another popular nootropic which positively affects your mood and helps fight anxiety. Take 20 mg along with Adrafinil to take the edge off when facing important cognitive tasks and attack them with a more calm and clear mind.

  • Milk Thistle

Because Adrafinil puts a significant strain on your liver, adding milk thistle is something I would definitely recommend when considering your general health. Milk thistle is a natural extract, popular in fighting liver damage and taking approximately 50-150 mg will profoundly reduce potential risks of liver problems when taking Adrafinil.

Adrafinil Reviews

Based on its efficacy and side effects, Modafinil might seem like a better choice of the two eugeroics.

Many though, still prefer Adrafinil over Modafinil because of its cost efficiency and lack of legal hassle of obtaining it.

Let’s take a look of what people have to say about their experience with Adrafinil:

“Started taking this recently to focus on trading stocks a bit better. Take it right in the morning before consuming food. I have been taking it down with some water and vitamin b complex. The results take about 25 minutes to kick in and I am in full throttle at about the 45 minute mark. Sometimes I have even taken this as a pre-workout supplement — and feel like it potentiates BETTER with exercise or a mild run than without! But I have to resupplement is about a few hours after to keep the same effect. I do cycle it though.”

“It works. Though it’s VERY subtle when taken in a completely rested/non-sleep deprived state; I wouldn’t recommend taking it when fully rested. One caveat for some out there: as with many other stimulants, from amphetamines, to the beta-adrenergic agonists, clenbuterol and ephedrine, etc, coffee/caffeine greatly potentiates the effects of this drug. Though, the major difference in the potentiation is a hugeee augmentation of anxiety. The focus and energy is amazing – I spent many a sleep deprived state in the lab with this combo and was very efficient. I just wanted to point out that those actually prone to anxiety (which I am not, at all) may want to heed that combo specifically.”

”I use it to stay awake and focused at work. I usually have a few hundred mg of caffeine from cheap energy drink and it’s really potentiated. I always used to only have a half modafinil tablet so I guess I’m sensitive, but I actually prefer adra! It certainly increases my endurance performance, did my first 50 miles cycle on it with a speed average of 15MPH and 2600 feet of climbing!”

“I play ice hockey in a city 2 hours away from me, and I have noticed a significant increase in my reaction time and focus while using Adrafinil approximately 5-6 hours before a game.”

“Adrafinil is probably the most powerful over the counter nootropic you can get. Just don’t use it every day and take it as early as possible. Start with 300mg and if you don’t get much from that you can go up to 600mg.”

“It will definitely help! But keep in mind it may keep you up for 12 hours, so up till 2AM if you take it at 2PM. “

Where to Order Adrafinil?

If you decided to order Adrafinil, I suggest ordering it here. 

Another great vendor for Adrafinil is this one >>

Both are reliable online vendors for nootropics with whom I have a great experience.

If you, however, would prefer ordering Modafinil, I do recommend ordering it here or here. 

Let me know how you like it!

Adrafinil Experience

Adrafinil Experience


  • What are the benefits of taking Adrafinil?

Very briefly, Adrafinil Improves alertness, motivation and focus for people who work for longer periods of time or at odd hours of the day.

  • Is it safe taking Adrafinil?

Yes, as long as you stick to the prescribed dosages and start out at the lower end of the spectrum, you should be fine.

  • Are there any side effects to taking Adrafinil?

Some people may experience nausea, stomach problems, headaches, lack of appetite and difficulty sleeping.

  • Can I take Adrafinil every day?

No. I suggest taking it only when you need it, or cycling it. Take it for two weeks, then give your body a one week break.

Your Inception Final Recommendation

Your Inception recommends supplementing Adrafinil.*

Adrafinil is a very powerful smart drug, similar to Modafinil.

It gives you a strong focus and energy. That’s what makes it such a powerful study drug.

While it works extremely well for most people, a small minority doesn’t really feel any benefits.

My personal experience with Adrafinil has been great, that’s why I recommend it.

*We recommend consulting your doctor before. 


  • 3Shares
  • 0
  • 0
  • 1
  • 0
  • 2

Please rate this

By |2019-07-05T18:03:47+00:00July 25th, 2018|Categories: Nootropics|Tags: , |0 Comments

About the Author:

Greg Gostincar is the founder of Your Inception. He has been researching, testing and experimenting with nootropics since 2015. Greg is one of the most recognized researchers in the field of nootropics.

Leave A Comment

Thanks !

Thanks for sharing this, you are awesome !