2. Lion’s Mane Benefits
What are the main Lion’s Mane Benefits? Let’s check them out:
Lion’s Mane Mushroom has been studied to increase NGF levels in the brain. NGF or Nerve Growth Factor is responsible for the maintenance and growth of neurons in the brain. It is a part of a large family of biomolecules known as neurotrophic factors. These biomolecules support the growth and survival of neurons.
The presence of NGF improves cognition by promoting the growth and branching of axons which are thread-like nerve extensions. The more healthy axons there are, the more efficiently they will conduct impulses. On the contrary, not enough NGF impairs cognition by triggering neural decay and the collapse of nerve cells.
Many neurological disorders such as Huntington’s disease and Parkinson’s are associated with neural degradation over time. It is believed that neurotrophic factors like NGF may play a part in preventing the onset of such conditions. 
Neurons have the potential to regenerate but need the right conditions to do so. For instance, a decrease in NGF levels can cause brain cells to die without being replaced. This impacts neurogenesis, which is the natural birth and growth of neurons.
As the human brain ages, the production of new neurons slows down. The old ones begin to die and when replacement gets slow, age-related diseases start to set in.
At the same time, neuroplasticity, which refers to the ability of the brain to change the structure, including the internal structure of neurons, also slows down. This means that your short and long-term memory suffers.
To prevent such issues with cognitive impairment, studies show that supplementing with Lion’s Mane may be beneficial to averting neural degeneration. 
Lion’s Mane Benefits
Poor immune response and function are the underlying causes of many chronic diseases. However, a response system known as immunomodulation can help support the immune system using biological cofactors along with nutrients and herbs. This response in critical or modifying the immune response to thoroughly defeat infections in the body.
In this respect, beta-glucans can be effective tools to modulate the immune system. However, these do not occur naturally within the body and need to be consumed from sources such as Lion’s Mane mushrooms among others.
Beta-glucans contain sugar molecules joined together. These branch-like structures bind and help specific immune cells to attack hostile targets. These modified responses support immunomodulation by stopping inflammation and an autoimmune response.
In addition, beta glucans also stimulate immune stem cells inside the bone marrow. This production releases new immunocytes into the blood and improves the immune response against potential invaders for everything from the common cold to tumor cell growth. 
Lion’s Mane bears an anti-inflammatory effect by a few different mechanisms. For instance, it reduces excessive nitric oxide which is an important signaling molecule and a component of the inflammatory response. 
Lion’s Mane also regulates prostaglandin production. Prostaglandins get produced in response to infection or injury causing inflammation. While this is an important part of the body’s healing process, this natural process can sometimes lead to excess and chronic production of prostaglandins. This can lead to inflammatory conditions brought on by unwanted inflammation. When this happens to supplement with Lion’s Mane can help regulate inflammation. 
Other areas where Lion’s Mane shows anti-inflammatory activities is by reducing pro-inflammatory cytokines as well as oxidative stress. Together all these mechanisms can have a significant impact on conditions such as autoimmune diseases, digestive disorders, metabolic disorders and much more.
The immune-strengthening effects of this edible mushroom can have immense benefits for cancer patients who already suffer from compromised immune systems. In such individuals, this can happen either due to the disease itself or by the strong and sometimes toxic anticancer therapies they need to undergo.
In this regard, one animal study shows Lion’s Mane extracts to reduce the weight of transplanted colon tumors in mice. At the same time, the extracts also doubled the number of NK or Natural Killer cells while enhancing macrophage activation.
Of these, NK are a kind of white blood cells that target and attack infected cancerous cells. And macrophages are another white blood cell type which disposes of anything not identifiable as healthy or normal body tissue including cancer cells.
The study also showed that Lion’s Mane extract prevented angiogenesis. This is the process whereby new blood vessels form from old ones. When this happens, it becomes much easier for cancerous cells to spread and invade neighboring organs and tissues.
But when angiogenesis halts, this mechanism also stops and prevents benign tumors from becoming malignant. 
Lion’s Mane mushroom has also shown potential in reducing anxiety and depression. A study that involved investigating menopausal symptoms such as irritability, loss of concentration, and anxiety all went down when treated with Lion’s Mane. 
In addition, when these bothersome symptoms subsided, subjects also reported improved sleep quality.
One component of Lion’s Mane known as amyceneon has shown antidepressant in animal studies. 
There is also some evidence that depressive symptoms may be linked to neurological inflammation and given its anti-inflammatory effects, Lion’s Mane may be able to ward off such unwanted emotional responses.